<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e6f4e-3bf0-7911-9613-f90f871a0e87,g:31b24744-1b68-455e-84ea-4450e56edfa3-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://indivior.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="indv-20260630.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://indivior.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e6f4e-3cc9-7844-b30d-de118fc40c60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e6f4e-3cc9-75e7-8352-24e034420b18" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e6f4e-3cc9-7844-b30d-de118fc40c60" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e6f4e-3cc9-75e7-8352-24e034420b18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019e6f4e-3cc9-7c33-8281-94e96a6311d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e6f4e-3cc9-7844-b30d-de118fc40c60" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019e6f4e-3cc9-7c33-8281-94e96a6311d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e6f4e-3cc9-7ce8-931c-c78836f7be07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e6f4e-3cc9-79f6-b204-3f5f8e3169ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e6f4e-3cc9-7ce8-931c-c78836f7be07" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e6f4e-3cc9-79f6-b204-3f5f8e3169ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e6f4e-3cc9-72e1-929f-fc8cac99356a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e6f4e-3cc9-7ce8-931c-c78836f7be07" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e6f4e-3cc9-72e1-929f-fc8cac99356a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e6f4e-3cc9-7be9-bcaa-bd3202dc5d0c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e6f4e-3cc9-78da-bb80-bff505430369" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e6f4e-3cc9-7be9-bcaa-bd3202dc5d0c" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e6f4e-3cc9-78da-bb80-bff505430369" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019e6f4e-3cc9-7cb2-b69f-370338b1e2a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e6f4e-3cc9-7be9-bcaa-bd3202dc5d0c" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019e6f4e-3cc9-7cb2-b69f-370338b1e2a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e6f4e-3cc9-7064-afd9-4396e1b7fc84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e6f4e-3cc9-7be9-bcaa-bd3202dc5d0c" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019e6f4e-3cc9-7064-afd9-4396e1b7fc84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e6f4e-3cc9-74f7-869f-90c88b477f26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e6f4e-3cc9-7be9-bcaa-bd3202dc5d0c" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e6f4e-3cc9-74f7-869f-90c88b477f26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e6f4e-3cc9-7a4f-958a-96ced5ffcece" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e6f4e-3cc9-7e17-a863-fe04e03ebc27" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e6f4e-3cc9-7a4f-958a-96ced5ffcece" xlink:to="loc_us-gaap_GrossProfit_019e6f4e-3cc9-7e17-a863-fe04e03ebc27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e6f4e-3cc9-70e9-94b7-0263dfbaa9dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e6f4e-3cc9-7a4f-958a-96ced5ffcece" xlink:to="loc_us-gaap_OperatingExpenses_019e6f4e-3cc9-70e9-94b7-0263dfbaa9dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e6f4e-3cc9-77c3-9dfe-4bd97938891c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e6f4e-3cc9-7c29-8dcb-6eacb8c94eca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e6f4e-3cc9-77c3-9dfe-4bd97938891c" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e6f4e-3cc9-7c29-8dcb-6eacb8c94eca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019e6f4e-3cc9-7668-b0bb-56de31b7e2ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e6f4e-3cc9-77c3-9dfe-4bd97938891c" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019e6f4e-3cc9-7668-b0bb-56de31b7e2ae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="indv-20260630.xsd#CondensedConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://indivior.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e6f4e-3cc9-73fb-beaa-aac8a5b15fe9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019e6f4e-3cc9-7ccb-bbbc-d0f91e7c2f9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e6f4e-3cc9-73fb-beaa-aac8a5b15fe9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019e6f4e-3cc9-7ccb-bbbc-d0f91e7c2f9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e6f4e-3cc9-7aca-b42f-1b2548e769f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e6f4e-3cc9-71e2-90db-e3385ca556d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e6f4e-3cc9-7aca-b42f-1b2548e769f5" xlink:to="loc_us-gaap_NetIncomeLoss_019e6f4e-3cc9-71e2-90db-e3385ca556d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e6f4e-3cc9-70d3-a285-3c0a7f1b3556" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e6f4e-3cc9-7aca-b42f-1b2548e769f5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e6f4e-3cc9-70d3-a285-3c0a7f1b3556" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="indv-20260630.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://indivior.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-7f36-8aa2-f9dcd7d0c95b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e6f4e-3cc9-70a6-82d5-8f7b8af985da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-7f36-8aa2-f9dcd7d0c95b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e6f4e-3cc9-70a6-82d5-8f7b8af985da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e6f4e-3cc9-75af-b329-5246e62999bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-7f36-8aa2-f9dcd7d0c95b" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019e6f4e-3cc9-75af-b329-5246e62999bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e6f4e-3cc9-76e2-874e-bd18d5ad0967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-7f36-8aa2-f9dcd7d0c95b" xlink:to="loc_us-gaap_InventoryNet_019e6f4e-3cc9-76e2-874e-bd18d5ad0967" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_019e6f4e-3cc9-7af2-8a57-385499543137" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-7f36-8aa2-f9dcd7d0c95b" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_019e6f4e-3cc9-7af2-8a57-385499543137" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_019e6f4e-3cc9-75c2-92fe-0b6d2f356602" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-7f36-8aa2-f9dcd7d0c95b" xlink:to="loc_us-gaap_IncomeTaxesReceivable_019e6f4e-3cc9-75c2-92fe-0b6d2f356602" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019e6f4e-3cc9-7c9e-8c1f-d31a72e759e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-7f36-8aa2-f9dcd7d0c95b" xlink:to="loc_us-gaap_OtherAssetsCurrent_019e6f4e-3cc9-7c9e-8c1f-d31a72e759e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e6f4e-3cc9-73b6-a9bc-0b39d95ff195" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-764a-a369-e4a9bd78bd79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e6f4e-3cc9-73b6-a9bc-0b39d95ff195" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-764a-a369-e4a9bd78bd79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019e6f4e-3cc9-72b4-a8e2-a1b4fd47dd92" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e6f4e-3cc9-73b6-a9bc-0b39d95ff195" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019e6f4e-3cc9-72b4-a8e2-a1b4fd47dd92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveNoncurrent_019e6f4e-3cc9-7586-9b62-5b4645bda5af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e6f4e-3cc9-73b6-a9bc-0b39d95ff195" xlink:to="loc_us-gaap_LitigationReserveNoncurrent_019e6f4e-3cc9-7586-9b62-5b4645bda5af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e6f4e-3cc9-7d20-b2da-f7856931258f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e6f4e-3cc9-73b6-a9bc-0b39d95ff195" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e6f4e-3cc9-7d20-b2da-f7856931258f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e6f4e-3cc9-765e-ab91-0871e5279635" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e6f4e-3cc9-73b6-a9bc-0b39d95ff195" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e6f4e-3cc9-765e-ab91-0871e5279635" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e6f4e-3cc9-754c-becf-71611d1b84f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019e6f4e-3cc9-7e8a-bce6-b289453cc62c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e6f4e-3cc9-754c-becf-71611d1b84f9" xlink:to="loc_us-gaap_CommonStockValue_019e6f4e-3cc9-7e8a-bce6-b289453cc62c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019e6f4e-3cc9-7f1a-9b7b-280c99839a87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e6f4e-3cc9-754c-becf-71611d1b84f9" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019e6f4e-3cc9-7f1a-9b7b-280c99839a87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e6f4e-3cc9-7f61-9016-0dd0de288e4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e6f4e-3cc9-754c-becf-71611d1b84f9" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e6f4e-3cc9-7f61-9016-0dd0de288e4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e6f4e-3cc9-740a-865f-d4143b936729" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e6f4e-3cc9-754c-becf-71611d1b84f9" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e6f4e-3cc9-740a-865f-d4143b936729" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e6f4e-3cc9-72c6-ab28-19829aab9fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e6f4e-3cc9-7167-bdba-75310f4786c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e6f4e-3cc9-72c6-ab28-19829aab9fb9" xlink:to="loc_us-gaap_Liabilities_019e6f4e-3cc9-7167-bdba-75310f4786c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019e6f4e-3cc9-79f1-817b-f8343557beb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e6f4e-3cc9-72c6-ab28-19829aab9fb9" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019e6f4e-3cc9-79f1-817b-f8343557beb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e6f4e-3cc9-732a-a12b-0145eea42c8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e6f4e-3cc9-72c6-ab28-19829aab9fb9" xlink:to="loc_us-gaap_StockholdersEquity_019e6f4e-3cc9-732a-a12b-0145eea42c8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-74b3-b5b5-938c5fc37226" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:to="loc_us-gaap_AssetsCurrent_019e6f4e-3cc9-74b3-b5b5-938c5fc37226" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_019e6f4e-3cc9-72b6-9bae-31b0e2e9c069" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:to="loc_us-gaap_LongTermInvestments_019e6f4e-3cc9-72b6-9bae-31b0e2e9c069" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e6f4e-3cc9-7cc8-8fe9-abbe8495b7ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e6f4e-3cc9-7cc8-8fe9-abbe8495b7ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e6f4e-3cc9-7bf1-b0c8-e9bf384cdd87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e6f4e-3cc9-7bf1-b0c8-e9bf384cdd87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_019e6f4e-3cc9-7929-842e-0922d9c41545" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_019e6f4e-3cc9-7929-842e-0922d9c41545" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e6f4e-3cc9-7a6b-9d8c-a278b96992f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e6f4e-3cc9-7a6b-9d8c-a278b96992f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e6f4e-3cc9-7d68-b2af-373cd05ce366" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e6f4e-3cc9-78a1-9237-5c86bc4df967" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e6f4e-3cc9-7d68-b2af-373cd05ce366" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-79c2-97f1-cc17ce37e457" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_019e6f4e-3cc9-799f-a2c7-3030773c143f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerRefundLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-79c2-97f1-cc17ce37e457" xlink:to="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_019e6f4e-3cc9-799f-a2c7-3030773c143f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-72d4-92ba-c756c451f9ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-79c2-97f1-cc17ce37e457" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-72d4-92ba-c756c451f9ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_019e6f4e-3cc9-7429-9e35-aee5cdb42e39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-79c2-97f1-cc17ce37e457" xlink:to="loc_us-gaap_LitigationReserveCurrent_019e6f4e-3cc9-7429-9e35-aee5cdb42e39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019e6f4e-3cc9-7ba0-bfcb-1244af6e4b3c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-79c2-97f1-cc17ce37e457" xlink:to="loc_us-gaap_LongTermDebtCurrent_019e6f4e-3cc9-7ba0-bfcb-1244af6e4b3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e6f4e-3cc9-7bfa-9309-9ba4ad0dc58b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-79c2-97f1-cc17ce37e457" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e6f4e-3cc9-7bfa-9309-9ba4ad0dc58b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019e6f4e-3cc9-71df-8885-6cf9b7dc5eb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e6f4e-3cc9-79c2-97f1-cc17ce37e457" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019e6f4e-3cc9-71df-8885-6cf9b7dc5eb4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="indv-20260630.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://indivior.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019e6f4e-3cc9-7b77-9dbd-8c03538c3d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019e6f4e-3cc9-7b77-9dbd-8c03538c3d2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e6f4e-3cc9-7ed8-af2b-5ff3a1fe5469" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e6f4e-3cc9-7ed8-af2b-5ff3a1fe5469" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019e6f4e-3cc9-7ad4-815a-12e2713c3b2f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019e6f4e-3cc9-7ad4-815a-12e2713c3b2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019e6f4e-3cc9-7991-a20d-f5abd6b0a697" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019e6f4e-3cc9-7991-a20d-f5abd6b0a697" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019e6f4e-3cc9-7698-8a31-87ebd1256bd2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019e6f4e-3cc9-7698-8a31-87ebd1256bd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_019e6f4e-3cc9-723b-9273-ee052bf21da1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_019e6f4e-3cc9-723b-9273-ee052bf21da1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e6f4e-3cc9-7fa2-b444-cc5103050d5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-724a-9675-e7cfede7c96a" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e6f4e-3cc9-7fa2-b444-cc5103050d5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e6f4e-3cc9-769f-ae98-67e569d0da06" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_NetIncomeLoss_019e6f4e-3cc9-769f-ae98-67e569d0da06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e6f4e-3cc9-7334-9998-07e81acda9be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e6f4e-3cc9-7334-9998-07e81acda9be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019e6f4e-3cc9-74ee-a256-60f13c0839a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019e6f4e-3cc9-74ee-a256-60f13c0839a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e6f4e-3cc9-7b08-8455-17a10a3ce918" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_ShareBasedCompensation_019e6f4e-3cc9-7b08-8455-17a10a3ce918" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019e6f4e-3cc9-7f76-b2e4-33e17e906a72" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_AssetImpairmentCharges_019e6f4e-3cc9-7f76-b2e4-33e17e906a72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e6f4e-3cc9-75cc-a82e-701290f30556" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e6f4e-3cc9-75cc-a82e-701290f30556" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019e8ba4-e91e-7742-bdd2-c787219d852b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019e8ba4-e91e-7742-bdd2-c787219d852b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e6f4e-3cc9-7adb-98df-2b1c3230e866" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e6f4e-3cc9-7adb-98df-2b1c3230e866" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019e6f4e-3cc9-7e7f-b646-331215ab1578" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019e6f4e-3cc9-7e7f-b646-331215ab1578" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_019f6921-ef74-702c-b056-f65fdcff78e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_019f6921-ef74-702c-b056-f65fdcff78e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019e6f4e-3cc9-7d35-8012-46b4bb9fe99d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019e6f4e-3cc9-7d35-8012-46b4bb9fe99d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e6f4e-3cc9-7b5f-9d5a-9a99e251f0f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e6f4e-3cc9-7b5f-9d5a-9a99e251f0f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019e6f4e-3cc9-7f14-a06f-7a0726a1d076" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019e6f4e-3cc9-7f14-a06f-7a0726a1d076" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019e6f4e-3cc9-7114-a210-f88b6b67a7c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019e6f4e-3cc9-7114-a210-f88b6b67a7c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_indv_IncreaseDecreaseInEstimatedLitigationLiability_019e6f4e-3cc9-78e8-aa03-156c5b51fd0b" xlink:href="indv-20260630.xsd#indv_IncreaseDecreaseInEstimatedLitigationLiability"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_indv_IncreaseDecreaseInEstimatedLitigationLiability_019e6f4e-3cc9-78e8-aa03-156c5b51fd0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019e6f4e-3cc9-7a7e-a414-d2e64e6d806d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7b9f-aa97-a83bc57c3df7" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019e6f4e-3cc9-7a7e-a414-d2e64e6d806d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e6f4e-3cc9-7034-94ac-d4ce23d3e776" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e6f4e-3cc9-74f5-8ecb-9375df59e8ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e6f4e-3cc9-7034-94ac-d4ce23d3e776" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e6f4e-3cc9-74f5-8ecb-9375df59e8ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_019e8ba5-bd39-7f6b-b42b-a5ae40bd3f88" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e6f4e-3cc9-7034-94ac-d4ce23d3e776" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_019e8ba5-bd39-7f6b-b42b-a5ae40bd3f88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_019e6f4e-3cc9-724b-9146-c71b58e7301c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireHeldToMaturitySecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e6f4e-3cc9-7034-94ac-d4ce23d3e776" xlink:to="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_019e6f4e-3cc9-724b-9146-c71b58e7301c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities_019e6f4e-3cc9-7a8c-847f-9daf0fc2ded3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e6f4e-3cc9-7034-94ac-d4ce23d3e776" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities_019e6f4e-3cc9-7a8c-847f-9daf0fc2ded3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e6f4e-3cc9-7e90-ade1-72caf61aab22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7568-bc2d-d1532682b530" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e6f4e-3cc9-7e90-ade1-72caf61aab22" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e6f4e-3cc9-7568-bc2d-d1532682b530" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e6f4e-3cc9-75d8-847b-1e7a410e3457" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e6f4e-3cc9-7e90-ade1-72caf61aab22" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e6f4e-3cc9-75d8-847b-1e7a410e3457" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-7d5c-a288-1ec4f2e7d7b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e6f4e-3cc9-7e90-ade1-72caf61aab22" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e6f4e-3cc9-7d5c-a288-1ec4f2e7d7b1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/InventoriesSummaryofInventoriesDetails" xlink:type="simple" xlink:href="indv-20260630.xsd#InventoriesSummaryofInventoriesDetails"/>
  <link:calculationLink xlink:role="http://indivior.com/role/InventoriesSummaryofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_indv_TotalInventoriesNetCurrentAndNoncurrent_019e6f4e-3cc9-7e5e-91a7-ff2cd42d37bd" xlink:href="indv-20260630.xsd#indv_TotalInventoriesNetCurrentAndNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_indv_InventoryRawMaterialsAndSuppliesNetOfReservesCurrentAndNoncurrent_019e6f4e-3cc9-7bdd-af77-3d382da72c8a" xlink:href="indv-20260630.xsd#indv_InventoryRawMaterialsAndSuppliesNetOfReservesCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_indv_TotalInventoriesNetCurrentAndNoncurrent_019e6f4e-3cc9-7e5e-91a7-ff2cd42d37bd" xlink:to="loc_indv_InventoryRawMaterialsAndSuppliesNetOfReservesCurrentAndNoncurrent_019e6f4e-3cc9-7bdd-af77-3d382da72c8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e6f4e-3cc9-7153-b3ae-c86c6409f866" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_indv_TotalInventoriesNetCurrentAndNoncurrent_019e6f4e-3cc9-7e5e-91a7-ff2cd42d37bd" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e6f4e-3cc9-7153-b3ae-c86c6409f866" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e6f4e-3cc9-7ae6-9804-bc932ae295cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_indv_TotalInventoriesNetCurrentAndNoncurrent_019e6f4e-3cc9-7e5e-91a7-ff2cd42d37bd" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e6f4e-3cc9-7ae6-9804-bc932ae295cd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/PropertyPlantandEquipmentNetSummaryofPropertyPlantandEquipmentNetDetails" xlink:type="simple" xlink:href="indv-20260630.xsd#PropertyPlantandEquipmentNetSummaryofPropertyPlantandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://indivior.com/role/PropertyPlantandEquipmentNetSummaryofPropertyPlantandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e6f4e-3cc9-76c3-9f5b-77059df47210" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019e6f4e-3cc9-706d-b0c8-db91aa20403e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e6f4e-3cc9-76c3-9f5b-77059df47210" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019e6f4e-3cc9-706d-b0c8-db91aa20403e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e6f4e-3cc9-7bf5-9c3f-c670f398036c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e6f4e-3cc9-76c3-9f5b-77059df47210" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e6f4e-3cc9-7bf5-9c3f-c670f398036c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/AccountsPayableandAccruedExpensesDetails" xlink:type="simple" xlink:href="indv-20260630.xsd#AccountsPayableandAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://indivior.com/role/AccountsPayableandAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-7dd3-a031-e3608ce3cd20" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019e6f4e-3cc9-75bd-8877-a13893c3e5bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-7dd3-a031-e3608ce3cd20" xlink:to="loc_us-gaap_AccountsPayableCurrent_019e6f4e-3cc9-75bd-8877-a13893c3e5bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e6f4e-3cc9-7abe-80da-30b58a2824cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-7dd3-a031-e3608ce3cd20" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e6f4e-3cc9-7abe-80da-30b58a2824cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccrualForTaxesOtherThanIncomeTaxesCurrent_019e6f4e-3cc9-7d22-9686-d8345500f52f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccrualForTaxesOtherThanIncomeTaxesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-7dd3-a031-e3608ce3cd20" xlink:to="loc_us-gaap_AccrualForTaxesOtherThanIncomeTaxesCurrent_019e6f4e-3cc9-7d22-9686-d8345500f52f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_019e6f4e-3cc9-7b69-958f-ad5f567b29e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-7dd3-a031-e3608ce3cd20" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_019e6f4e-3cc9-7b69-958f-ad5f567b29e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e6f4e-3cc9-7ead-bc7f-7fb8d04642c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e6f4e-3cc9-7dd3-a031-e3608ce3cd20" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e6f4e-3cc9-7ead-bc7f-7fb8d04642c4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/AccruedLitigationSettlementExpensesSummaryDetails" xlink:type="simple" xlink:href="indv-20260630.xsd#AccruedLitigationSettlementExpensesSummaryDetails"/>
  <link:calculationLink xlink:role="http://indivior.com/role/AccruedLitigationSettlementExpensesSummaryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserve_019e6f4e-3cc9-7a2e-808e-45be5ea0aba0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserve"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_019e6f4e-3cc9-7cbc-aa0d-aee9bf9e920d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LitigationReserve_019e6f4e-3cc9-7a2e-808e-45be5ea0aba0" xlink:to="loc_us-gaap_LitigationReserveCurrent_019e6f4e-3cc9-7cbc-aa0d-aee9bf9e920d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveNoncurrent_019e6f4e-3cc9-71f3-b6f3-3f8c44c82eda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LitigationReserve_019e6f4e-3cc9-7a2e-808e-45be5ea0aba0" xlink:to="loc_us-gaap_LitigationReserveNoncurrent_019e6f4e-3cc9-71f3-b6f3-3f8c44c82eda" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://indivior.com/role/EarningsPerShareCalculationofEarningsPerShareDetails" xlink:type="simple" xlink:href="indv-20260630.xsd#EarningsPerShareCalculationofEarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://indivior.com/role/EarningsPerShareCalculationofEarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e6f4e-3cc9-7a79-9084-3e7da5a2b61d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e6f4e-3cc9-7478-8e98-fca39cdebc1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e6f4e-3cc9-7a79-9084-3e7da5a2b61d" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e6f4e-3cc9-7478-8e98-fca39cdebc1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e6f4e-3cc9-7ed9-b2db-c6de73185808" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e6f4e-3cc9-7a79-9084-3e7da5a2b61d" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e6f4e-3cc9-7ed9-b2db-c6de73185808" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
